Directed Evolution and Biocatalysis
نویسندگان
چکیده
منابع مشابه
Directed Molecular Evolution – Applications in Biocatalysis
drug discovery are announced on a regular basis, it is rare for an entirely new technology to emerge within the pharmaceutical bulk active and synthesis sector. Such a technology – developed by Codexis, Inc – enables the rapid discovery and development of novel or improved processes for the cost-effective synthesis of chemicals, using breakthrough biocatalysts and fermentation strains. Furtherm...
متن کاملRecent advances in biocatalysis by directed enzyme evolution.
Naturally occurring enzymes are remarkable biocatalysts with numerous potential applications in industry and medicine. However, many of their catalyst properties often need to be further tailored to meet the specific requirements of a given application. Within this context, directed evolution has emerged over the past decade as a powerful tool for engineering enzymes with new or improved functi...
متن کاملDesign by Directed Evolution
The stunning array of features and functions exhibited by proteins in nature should convince most scientists of the power of evolutionary design processes. Natural selection acting on populations over long periods of time has generated a vast number of proteins ideally suited to their biological functions. When we try to recruit these remarkable molecular machines for new taskssfrom serving as ...
متن کاملDirected polymerase evolution.
Polymerases evolved in nature to synthesize DNA and RNA, and they underlie the storage and flow of genetic information in all cells. The availability of these enzymes for use at the bench has driven a revolution in biotechnology and medicinal research; however, polymerases did not evolve to function efficiently under the conditions required for some applications and their high substrate fidelit...
متن کاملLaboratory-directed protein evolution.
Systematic approaches to directed evolution of proteins have been documented since the 1970s. The ability to recruit new protein functions arises from the considerable substrate ambiguity of many proteins. The substrate ambiguity of a protein can be interpreted as the evolutionary potential that allows a protein to acquire new specificities through mutation or to regain function via mutations t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2002
ISSN: 1433-7851
DOI: 10.1002/1521-3773(20020201)41:3<382::aid-anie2222382>3.0.co;2-s